OK, so set up a filtration system. If you're good enough to build a system capable of running at that level you should be able to set up some basic mail filters or even a more complex bayesian filter to knock out at least bounces and probably a good percentage of autoreplies too.
Removing noise from a system isn't a job where it's perfect or useless; a substantial reduction is often quite good enough.
I don't see why it's necessary to make this complicated: "friendlyrobot" is the filtration system. As you said, it doesn't need to be perfect to be useful.